臨床研究開発部

臨床研究開発部

中島 淳
臨床研究・開発部では、臨床研究および治療法の開発などを行います。特に非アルコール性脂肪性肝疾患(NAFLD)に関しては、全国の多施設共同研究グループJapan Study Group of NAFLD (JSG-NAFLD)を組織し、多くの業績を蓄積しています。協賛企業との連携により、機能性食品の開発も行います。

中島 淳 なかじまあつし
横浜市立大学大学院医学研究科
肝胆膵消化器病学教室 主任教授

平成元年大阪大学卒業
平成元年-4年社会保険中央総合病院内科
平成6年 茅ヶ崎市立病院
平成9年 東京大学第三内科助手
平成10年ハーバード大学客員研究員
平成26年横浜市立大学大学院医学研究科 肝胆膵消化器病学教室主任教授

非アルコール性脂肪肝疾患(NAFLD)ガイドライン作成メンバー

論文業績 英語論文550報
最近5年間の論文抜粋
  1. Clinical Gastroenterology and Hepatology, 2019(アジア11か国とのNAFLD診断におけるエラストグラフィーの有用性の国際共同研究)
  2. Clinical Gastroenterology and Hepatology, 2018(メイヨークリニック放射線科とのMRE共同試験)
  3. Lancet Oncology. 2016 (メトフォルミンによる大腸発がん予防の第3相試験)
  4. Gastroenterology. 2016(MRエラストグラフィーによるNASH非侵襲的診断臨床研究)
  5. Nature. 2014(粘膜免疫の基礎研究)
  6. Cell Metab. 2012(エンドトキシン肝臓の感受性亢進に関する基礎研究)

テレビ出演等
NHKスペシャル、ためしてガッテン、ガッテン、タケシの家庭の医学、世界一受けたい授業、BS夢の扉、今日の健康(多数)など。



  • 患者さんとご家族のためのNAFLD/NASHガイド (日本消化器病学会編)
  • Facebook:JSG-NAFLD
  • JSG-NAFLDメンバーによる主な書籍のご紹介
    • [18] Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A), Chayama K, Saibara T, Shima T, Fujimoto K, Okanoue T, Itoh Y; Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD). The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study.J Gastroenterol. 2018 Nov;53(11):1216-1224. doi: 10.1007/s00535-018-1474-y. Epub 2018 May 9.
    • [17] Kawaguchi T, Tokushige K, Hyogo H, Aikata H, Nakajima T, Ono M,Kawanaka M, Sawada K, Imajo K, Honda K, Takahashi H, Mori K,Tanaka S(12), Seko Y, Nozaki Y, Kamada Y, Fujii H, Kawaguchi A, Takehara T, Yanase M, Sumida Y, Eguchi Y, Seike M,Yoneda M, Suzuki Y, Saibara T, Karino Y, Chayama K, Hashimoto E, George J, Torimura T. A Data Mining-based Prognostic Algorithm for NAFLD-related Hepatoma Patients: A Nationwide Study by the Japan Study Group of NAFLD. Sci Rep. 2018 Jul 11;8(1):10434. doi: 10.1038/s41598-018-28650-0.
    • [16] non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2019 Jan 1. doi: 10.1111/jgh.14595. [Epub ahead of print]
    • [15] Fujii H, Imajo K, Yoneda M, Nakahara T, Hyogo H, Takahashi H, Hara T, Tanaka S, Sumida Y, Eguchi Y, Chayama K, Nakajima A, Nishimoto N, Kawada N; Japan Study Group of Nonalcoholic Fatty Liver Disease. HOMA-IR: An independent predictor of advanced liver fibrosis in nondiabetic
    • [14] Sumida Y, Yoneda M, Hyogo H, Yamaguchi K, Ono M, Fujii H, Eguchi Y, Suzuki Y, Imai S, Kanemasa K, Fujita K, Chayama K, Yasui K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease. J Gastroenterol. 2011 Feb;46(2):257-68.
    • [13] Sumida Y, Yoneda M, Hyogo H, Itoh Y, Ono M, Fujii H, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Fujita K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population. BMC Gastroenterol. 2012 Jan 5;12:2.
    • [12] Eguchi Y, Hyogo H, Ono M, Mizuta T, Ono N, Fujimoto K, Chayama K, Saibara T;JSG-NAFLD. Prevalence and associated metabolic factors of nonalcoholic fatty liver disease in the general population from 2009 to 2010 in Japan: a multicenter large retrospective study. J Gastroenterol. 2012 May;47(5):586-95.
    • [11] Yoneda M, Imajo K, Eguchi Y, Fujii H, Sumida Y, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Aoki N, Sata M, Kanemasa K, Kohgo Y, Saibara T, Chayama K, Itoh Y, Yoshikawa T, Anzai K, Fujimoto K, Okanoue T, Nakajima A; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). Noninvasive scoring systems in patients with nonalcoholic fatty liver disease with normal alanine aminotransferase levels. J Gastroenterol. 2013 Sep;48(9):1051-60.
    • [10] Kitajima Y, Hyogo H, Sumida Y, Eguchi Y, Ono N, Kuwashiro T, Tanaka K, Takahashi H, Mizuta T, Ozaki I, Eguchi T, Kimura Y, Fujimoto K, Anzai K; Japan Nonalcoholic Fatty Liver Disease Study Group (JSG-NAFLD). Severity of non-alcoholic steatohepatitis is associated with substitution of adipose tissue in skeletal muscle. J Gastroenterol Hepatol. 2013 Sep;28(9):1507-14.
    • [9] Yoneda M, Fujii H, Sumida Y, Hyogo H, Itoh Y, Ono M, Eguchi Y, Suzuki Y, Aoki N, Kanemasa K, Imajo K, Chayama K, Saibara T, Kawada N, Fujimoto K, Kohgo Y, Yoshikawa T, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease. Platelet count for predicting fibrosis in nonalcoholic fatty liver disease. J Gastroenterol. 2011 Nov;46(11):1300-6.
    • [8] Taketani H, Sumida Y, Tanaka S, Imajo K, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Kanemasa K, Chayama K, Itoh Y, Yoshikawa T, Saibara T, Fujimoto K, Nakajima A; Japan Study Group of NAFLD. The association of insomnia with gastroesophageal reflux symptoms in biopsy-proven nonalcoholic fatty liver disease. J Gastroenterol. 2014 Jul;49(7):1163-74.
    • [7] Nakahara T, Hyogo H, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Ono M, Kawaguchi T, Imajo K, Aikata H, Tanaka S, Kanemasa K, Fujimoto K, Anzai K, Saibara T, Sata M, Nakajima A, Itoh Y, Chayama K, Okanoue T; Japan Study Group of Nonalcoholic Fatty Liver Disease. Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients. J Gastroenterol. 2014 Nov;49(11):1477-84.
    • [6] Tanaka K, Hyogo H, Ono M, Takahashi H, Kitajima Y, Ono N, Eguchi T, Fujimoto K, Chayama K, Saibara T, Anzai K, Eguchi Y; Japan Study Group of Non-alcoholic Fatty Liver Disease (JSG-NAFLD). Upper limit of normal serum alanine aminotransferase levels in Japanese subjects. Hepatol Res. 2014 Nov;44(12):1196-207.
    • [5] Kessoku T, Yoneda M, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Kawaguchi T, Nakajima A; Japan Study Group of NAFLD. Insulin resistance correlated with the severity of liver histology in Japanese NAFLD patients: a multicenter retrospective study. J Clin Gastroenterol. 2015 Feb;49(2):169-70.
    • [4] Eguchi Y, Kitajima Y, Hyogo H, Takahashi H, Kojima M, Ono M, Araki N, Tanaka K, Yamaguchi M, Matsuda Y, Ide Y, Otsuka T, Ozaki I, Ono N, Eguchi T, Anzai K; Japan Study Group for NAFLD (JSG-NAFLD). Pilot study of liraglutide effects in non-alcoholic steatohepatitis and non-alcoholic fatty liver disease with glucose intolerance in Japanese patients (LEAN-J). Hepatol Res. 2015 Mar;45(3):269-78.
    • [3] Kessoku T, Ogawa Y, Yoneda M, Imajo K, Sumida Y, Eguchi Y, Fujii H, Hyogo H, Ono M, Suzuki Y, Kawaguchi T, Chayama K, Tanaka S, Fujimoto K, Anzai K, Saibara T, Sata M, Itoh Y, Nakajima A, Okanoue T; Japan Study Group of NAFLD (JSG-NAFLD). Simple scoring system for predicting cirrhosis in nonalcoholic fatty liver disease. World J Gastroenterol. 2014 Aug 7;20(29):10108-14.
    • [2] Sumida Y, Seko Y, Yoneda M; Japan Study Group of NAFLD (JSG-NAFLD). Novel antidiabetic medications for non-alcoholic fatty liver disease with type 2 diabetes mellitus. Hepatol Res. 2017 Mar;47(4):266-280.
    • [1] Oeda S, Takahashi H, Yoshida H, Ogawa Y, Imajo K, Yoneda M, Koshiyama Y, Ono M, Hyogo H, Kawaguchi T, Fujii H, Nishino K, Sumida Y, Tanaka S, Kawanaka M, Torimura T, Saibara T, Kawaguchi A, Nakajima A, Eguchi Y; Japan Study Group of Nonalcoholic Fatty Liver Disease (JSG-NAFLD). Prevalence of pruritus in patients with chronic liver disease: A multicenter study. Hepatol Res. 2017 Sep 6. doi:10.1111/hepr.12978. [Epub ahead of print] PubMed PMID: 28877392.